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[1] [2] Some patients report reduced symptoms within weeks of starting treatment, whilst others may require several months of consistent supplementation before noticing significant improvement
This is called first-pass bypass, and it is the entire reason sublingual semaglutide and sublingual tirzepatide exist as alternatives to injections
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10.1210/endo-127-5-2217 45 LeiS.ClydesdaleL.DaiA.CaiX.FengY.YangD.et al (2018)
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Some individuals may experience mild injection site reactions, temporary fatigue, or slight headache
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