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In addition, hypothalamic ER stress induced by chronic over-nutrition induces hypothalamic insulin/leptin resistance, which causes obesity and T2DM in rats [126]
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SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), with 4-point MACE HR 0.88 and all-cause death HR 0.84: Heerspink SURPASS-4 kidney post-hoc
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