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Established ASCVD was defined as MI, stroke, any revascularization procedure, transient ischemic attack, unstable angina, amputation, symptomatic or asymptomatic coronary artery disease
Less tyrosinase activity means less eumelanin and a gradual shift toward a lighter, more even skin tone
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
Quality of life is significantly impacted by both early and late, and management is difficult, usually given in stepwise approach of dietary, medical or surgical re-intervention options [12]
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