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Because serum alanine aminotransferase (ALT) levels have been reported to predict the histological course of NASH and because strict control of ALT is required to prevent the progression of NASH [13], the primary outcome of this study was a change in ALT levels
Gut microbiota, immune system, and bone
Monitoring: Clinical response assessment rather than routine serum B12 measurement, as levels remain elevated following injection regardless of tissue adequacy
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[1] Retatrutide (trials): once-weekly subcutaneous administration, starting low (e.g., 2 mg) and escalating to 4, 8, or 12 mg maintenance, with slower titration used to improve tolerability
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