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Through the analysis of these binding interactions and dynamic behaviors, we intend to identify residues that significantly enhance affinity, assess reliable binding modes, and offer essential insights for the development of effective hTYR inhibitors

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Depression-related effects appear to be rare based on current clinical trial and post-marketing data

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While it found no significant reduction in MACE, it was one of the initial trials that helped expand the safety and tolerability information regarding oral GLP-1 RAs [20]