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Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use

J Pineal Res 30:6574

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Although liraglutide, semaglutide, and tirzepatide have become the predominant GLP-1 RAs for obesity management, exenatide remains a clinically relevant option, particularly for older adults managing both obesity and T2DM [70]