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Referenced in Pickart 2018 review

Factors Influencing the Effectiveness of Vitamin B12 Shots Several factors can influence how quickly and effectively a Vitamin B12 shot works: Severity of Deficiency : Individuals with severe Vitamin B12 deficiency may experience a more noticeable and rapid improvement in symptoms compared to those with mild deficiency

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DSIPs precise physiological role and mechanism of action continue to be subjects of ongoing research