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The market is huge

F inerenone (the only non-steroidal MRA approved by Food and Drug Administration and European Medicines Agency for the treatment of CKD associated with type 2 diabetes) and esaxerenone have the most comprehensive clinical data [193]

T., Leon-Velarde, F., Hurtado, A

Topical NSAIDs (such as ibuprofen gel) provide effective localised pain relief with minimal liver impact, whilst non-pharmacological approaches like physiotherapy, heat therapy, and weight management are safe and beneficial

Sex-specific differences in metabolic control, cardiovascular risk, and interventions in patients with type 2 diabetes mellitus