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Consistent with these findings, physiological measurements demonstrated that melatonin continued to improve airway function in the presence of Luzindole ( Figures 2O, P ), suggesting that receptor-independent mechanisms may contribute to melatonins protective effects in allergic airways disease

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In conclusion, metformin could ameliorate inflammation and oxidative stress in renal tubular cells, regulate apoptosis and autophagy, and attenuate tubulointerstitial damage through various mechanisms

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