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Major clinical trials did not report contraceptive failure as a significant safety signal

Cumulative loss by week eight is typically four to eight pounds, or roughly two to four percent of starting body weight

10.1002/jbmr.2905 12 ChavanS

Hypoglycemia risk Although the risk of hypoglycemia with these medications is generally low, combining them could potentially increase this risk, especially in patients also taking insulin or sulfonylureas