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In addition to summarizing individual parameters, an integrated redox profile was assigned to each brain region analyzed
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It is the only amino acid whose side chain terminates in a free sulfhydryl group, and that single thioljust one sulfur atom and one protonis what makes cysteine the rate-limiting precursor for glutathione synthesis, the structural lynchpin of disulfide bonds that hold secreted proteins and antibodies in their functional conformations, the catalytic nucleophile in the active sites of cysteine proteases and thioredoxin reductases, and the metabolic sensor whose oxidation state reports the redox poise of the entire cell
Probiotics improve the gut microbiota composition, regulate the immune system and synthesis of several bioactive metabolites
Perhaps, most importantly, when GSH does its job in detoxifying oxidants, the end productwhich is oxidized GSH and is written chemically as GSSH (also called glutathione disulfide)is not itself harmful and is safely and quickly recycled back to GSH
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