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A 2024 French study found that women who used the drug for at least one year were 5.6-times more likely to develop a brain tumor called an intracranial meningioma

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The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after initial weight loss regained approximately 14% of their body weight over 52 weeks, compared to those who continued treatment

Additionally, changes in cardiovascular health, though generally positive with weight loss, may initially influence blood flow dynamics

Exenatide exhibited similar glucose lowering efficacy to long-acting insulin glargine in patients with type 2 diabetes with suboptimal glycemic control despite metformin and sulfonylurea treatment [44]