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IGF-1 LR3 is a direct IGF-1 receptor agonist it bypasses the pituitary and liver entirely and acts directly on IGF-1 receptors in muscle, fat, and connective tissue
6,12 Conclusions Balanced meals that combine fiber, protein, and healthy fats can naturally increase GLP-1 activity, promoting satiety, maintaining optimal energy levels, and improving glucose control
In vitro models show it enhances superoxide dismutase activity for antioxidant effects and stimulates metalloproteinases for matrix turnover
PMID 10554220
Retatrutide at 12mg achieved 28.7% in 68 weeks, surpassing both
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