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Notably, lactylation also acts as a key mediator for some drugs in cerebral IRI protection, such as Buyang Huanwu Decoction, which effectively inhibits cerebral IRI deterioration by suppressing extensive lysine lactylation and specific H3K18 lactylation [117]
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Liver workload: Large amounts of caffeine may add strain to detox pathways
For instance, a systematic study stated that smokers in the HPV (+) the group had a lower likelihood of developing HNSCC compared to those in the HPV () group, implying a limited role of smoking in HPV-positive HNSCC cancer [168]
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