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Mutant TDP-43 activates M1 microglia and upregulates pro-inflammatory mediators NOX2, TNF-, and IL-1 (Beers et al., 2011

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In addition, pathway enrichment analysis was conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG) on the dataset obtained from RNA sequencing

Purified recombinant PCBP1 and PCBP2 were found to bind ferrous iron in vitro using isothermal titration calorimetry (ITC)

Studies have shown that GLP-1R agonists not only promote insulin secretion and exert glucose-lowering effects but also effectively delay gastric emptying, reduce intestinal motility, activate neural pathways in the hypothalamus and appetite regulation areas, resulting in decreased appetite and reduced food intake, thus treating obesity