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While it often does not cause bleeding, untreated gastritis can irritate the lining enough to cause small bleeds, leading to melena

PLoS One 9(3):e90353 Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H et al (2011) A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis

Here's what you should know going in: Commonly reported effects include nausea, vomiting, diarrhea, and constipation, particularly during initial dose escalation Warnings and precautions in the prescribing information for applicable semaglutide and tirzepatide products cover pancreatitis, gallbladder disease, and kidney injury associated with volume depletion If you're on insulin or sulfonylureas, discuss hypoglycemia risk with your prescriber - GLP-1 medications can affect blood sugar control when combined with those drugs These medications slow gastric emptying, which can affect how orally taken medications are absorbed - worth flagging if you take other oral drugs regularly Certain FDA-approved semaglutide and tirzepatide products carry a boxed warning concerning thyroid C-cell tumors observed in rodents

(Read my full article on the downsides of GLP-1s HERE.) Who Benefits Most