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doi: 10.2337/db14-1751 25 KoopmanADMRuttersFRauhSPNijpelsGHolstJJBeulensJWet al

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Butyrylcarnitine may be used as an analytical reference standard for the separation and identification of underivatized butyryl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS)

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This biological approach can achieve higher production yields for complex peptides but requires more sophisticated manufacturing infrastructure