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Decreases in LCAs and MCAs in E4s may reflect poor mitochondrial FAO capacity or alternatively increased cellular reliance on FAs to support bioenergetics in the cerebrovasculature
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Compared with mock cells, no apparent differences in concentrations of reduced or oxidized GSH were observed in GSTP1 -transfected cells
We will further look into this and explore how we can help patients with addiction, potentially with GLP-1, Lange said, also adding that it has to be addressed in a scientific, and obviously also from a regulatory perspective, very rigorous way so we can really see the potential impact of GLP-1 in that space. However, in response to questions from Biospace, a Novo spokesperson said that Lange was referring to the already ongoing work studying semaglutide on liver damage and alcohol use in its phase 2 trial, and that the company has no plans to study the drug in broader addiction indications
