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ITI = 2000, 3,000, or 4,000 ms)

These symptoms can escalate to life-threatening difficulties for individuals with comorbidities such as type II diabetes, frailty, heart disease and general aging

A stronger barrier also allows for better retention of nutrients, which is helpful for dry or sensitive areas

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First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death