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Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis
Similarly, the frequency of PT-141 observed side effects are generally dose dependent, with an increased incidence of flushing, nausea, noxious aftertaste, post-nasal drip, headache, rhinorrhea, and vomiting at higher doses
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However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials
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