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The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida

Early adopters like CON-CRT (whose founder Mark Faulkner co-founded Aegis Sciences Corporation, one of the industry's pioneering anti-doping labs), RedLeaf Biologics with ReDaxin (the first and only clinically studied patented red sorghum leaf extract made in the USA that's also the first to utilize TruShield certification), and Vireo (who certified their innovative Amino Activ topical product) recognized this value and chose testing that matches the rigor of elite athletic competition

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T2DM patients: Glycemic control is recommended to slow the progression of neuropathy