Angiogenesis and Wound Healing Models: In rodent excisional wound, burn, and ischemic flap models, co-administration promoted faster wound closure, greater vascularization (upregulated VEGF), increased keratinocyte and fibroblast migration (via TB-500s actin-binding effects), and superior granulation tissue formation
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A peptide that modulates VEGFR2 in a cell culture dish, or heals a rat tendon at 10 mcg/kg IP injection, has not been shown to survive oral delivery in a human at 500 mcg and reach musculoskeletal tissue at any meaningful concentration
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