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[12] [13] In contrast, NAD+ supplementation lacks comparable evidence and is not included in clinical practice guidelines for diabetes or obesity management

For patients without neurological involvement, the initial regimen is typically 1 mg intramuscularly three times weekly for 2 weeks

Patients with pre-existing hypotension or autonomic dysfunction may be at heightened risk of symptomatic low blood pressure, especially during the titration phase

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In rare cases, medical cannabis might be appropriate and can be prescribed legally in the UK by specialist clinicians for specific conditions