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Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation
The key consideration is understanding how both substances work in your body and recognising that their combined effects may be unpredictable or amplified in certain circumstances
The buffer type and concentration (molarity) further influence how quickly or slowly degradation occurs
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