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GSH inhibitors such as buthionine sulfoximine (BSO) were found to improve chemosensitivity in cancer cells
as the most potently reactive ROS species damages DNA by causing OH
Because its activity centers on angiogenesis modulation, study designs in oncology-adjacent contexts typically account for this mechanism
Data are plotted as means SD of six replicate experiments
This is not a new drug class, as it has been around since the discovery of exenatide (trade name Byetta) in the venom from the saliva of the Gila monster
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