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(1993) Biological Effects and Metabolic Rates of Glucagon-like Peptide-1 7-36 Amide and Glucagon-like Peptide-1 7-37 in Healthy Subjects are Indistinguishable
Southworth, T
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When you eat, GLP-1 does several important jobs: It tells your pancreas to release insulin, which moves sugar from your blood into your cells It stops your liver from making too much sugar It slows down how fast food leaves your stomach It signals your brain that youre full People with type 2 diabetes or obesity often dont make enough GLP-1, or their bodies dont respond to it well
This flexibility enabled regulators to tailor safety monitoring based on actual risk profiles observed during drug development, facilitating the approval of drugs like GLP-1R agonists for broader therapeutic use, including in non-diabetic populations with Cardiovascular-Kidney-Metabolic (CKM) Syndrome
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