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Yang K, Wang C, Sun T
Collectively, the metabolic flexibility provided by glutamine and arginine supports both the bioenergetic and biosynthetic needs of fibrotic tissues while sustaining a permissive microenvironment for chronic immune dysregulation and fibroblast persistence
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As of 2026, the paper has not been formally retracted, but the Expression of Concern remains in force
Nonetheless, insulin/IGF signaling has been demonstrated to attenuate inflammatory responses, e.g., in human myocardial infarction [21] and severe thermal trauma [22] as well as in many mouse models, such as colitis [23], vascular inflammation [24], IL-1-induced cartilage degradation [25], lipopolysaccharide-provoked brain injuries [26], and experimental multiple sclerosis and autoimmune diabetes [27, 28]
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