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If you're taking B12 to boost energy, support mood, or improve overall wellness, knowing when and how to take Vitamin B12 helps you feel the effects faster and more consistently

Once a glucuronidated conjugate is excreted into bile and reaches the intestine, certain gut bacteria produce an enzyme called beta-glucuronidase that cleaves the glucuronic acid group, liberating the original compound for reabsorption

It acts as the ultimate electron donor for the glutaredoxin system, which activates ribonucleotide reductase (RNR) , the rate-limiting enzyme responsible for converting ribonucleotides into the deoxyribonucleotides (dNTPs) needed for DNA replication

For that reason, medical supervision is essential

Enrique Caballero, an endocrinologist at Harvard-affiliated Brigham and Women's Hospital