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Alternatives include orlistat (though it may cause gastrointestinal side effects), structured lifestyle programmes with dietetic support, psychological interventions, tailored physical activity, and bariatric surgery for eligible patients

The TRANSCEND-T2D Phase 3 clinical trial program is evaluating the safety and efficacy of retatrutide for the treatment of adults with type 2 diabetes across three global registrational trials

However, a previous study has shown that cysteine starvation could increase the anticancer immune response of T cells (120)

To inhibit glycolysis, 2-Deoxy-D-glucose (2-DG, Sigma D8375) or galactose (D-(+)-Galactose, Sigma G0750) was used at the indicated concentration

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