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A serious problem of MS in the identification of metabolites is ion suppression, which is a kind of matrix effect and is mainly caused by the different volatility of metabolites, due to their different nature and structure, which in turn affects the output of the number of ions in the gas phase reaching the detector and eventually leads to errors in the quantification of the analysis (Annesley, 2003
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Based on data from RCTs in T1D and those with patients with T2D, initiation of a GLP-1RA should be followed by a decrease of total insulin dose to reduce events of hypoglycemia (71)
Matsui K, Hasegawa J, Tachibana M
Response rates at the highest dose proved particularly striking
