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All of this is receptor-level characterisation in transfected cell systems and recombinant complexes, and none of it constitutes evidence of any effect in humans
doi: 10.1007/s11940-018-0500-y [PubMed] 30516601 Nelson SE, Varelas PN
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The normal LH group did not show a response at either timepoint, suggesting a different neurochemical cause for their hypothalamic amenorrhea