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In 1994, a combination of dimethylfumarate and three salts of monoethylfumarate, Fumaderm, was approved in Germany for the treatment of psoriasis (Dunn 2013)
In 87% of Indian PsA patients, the nails show visible changes
Key findings include enhanced phosphorylation of Src, Caveolin-1, and eNOS, with the vasodilation effect being abolished by nitric oxide inhibitors
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