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While its exact mechanism is still being studied, we know it works primarily in the central nervous system

Janumet is dosed as follows: Janumet (immediate-release tablets): The typical starting dose is 50 mg/500 mg (sitagliptin/metformin) by mouth twice daily with meals Janumet XR (extended-release tablets): The typical starting dose is 100 mg/1,000 mg (sitagliptin/metformin) by mouth once daily with a meal Your dose might differ if you were taking metformin by itself before you started Janumet

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