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And those opportunities are growing, as 8% to 10% of Americans now take a GLP-1 and 30% to 35% have indicated interest in taking one, according to PricewaterhouseCoopers
Aging Cell 10 , 551554 (2011)
Oral administration would break it down in the digestive tract
Patients carrying certain genetic patterns may experience stronger appetite suppression at lower doses, while others require higher doses to achieve comparable results
Specific digestive enzymes, most notably gamma-glutamyltransferase (GGT) and various intestinal peptidases, cleave the tripeptide into its constituent amino acids long before it can reach systemic circulation intact
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