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MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications
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J Biol Chem 291:980988 Sayers SR, Reimann F, Gribble FM et al (2016) Proglucagon promoter cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance
Like GHRS-R1a, the G protein-coupled GLP-1 receptor (GLP-1R) is also expressed in various regions of the CNS, including the hypothalamus, thalamus, brainstem, and cortical regions such as the insula, opercular cortex, frontal pole, and paracingulate gyrus (Drucker, 2022
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