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There are important similarities: the GI side effects of GLP1-RAs might be mitigated in the "maintenance" phase with new add-on drugs reducing the "induction" dose or just reducing the induction dose, while aiming to keep the weight reduction effects (="remission") for longer time (= longer duration)
Ozempic 0.5 mg solution for injection in pre-filled pen Summary of Product Characteristics (EMC)
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Significant caloric restriction or rapid weight loss may signal the body to down-regulate reproductive function as a protective mechanism, leading to anovulation or amenorrhoea
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