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In addition to studying the biological mechanisms of how changes in Eh Cys/CySS and Eh GSH/GSSG correlate with other markers of OS and influence redox sensitive redox signaling pathways, we plan on evaluating whether the balance of Cys/CySS and GSH/GSSG can differentiate subpopulations of critically ill children with differing severity of critical illness
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Not only does glutathione help regenerate these oxidation-regulating vitamins, it also functions as a cofactor for endogenous oxidation regulating enzymes such as glutathione peroxidase or glutathione-S-transferase
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