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Greater weight loss potential The SURMOUNT-5 trial, published in NEJM in 2025, directly compared tirzepatide against semaglutide in adults with obesity (without diabetes)
The list price of Ozempic is $968.52 for a 30-day supply, according to the manufacturer, Novo Nordisk
Metabolic changes that show up in bloodwork (better fasting glucose, improved A1c, lower triglycerides) take 6 to 8 weeks to register
Thyroid Status Optimization: Before initiating weight loss injections, hypothyroidism should be adequately controlled
Fasting Glucose Why it matters: While A1c provides a longer-term picture, fasting glucose captures your blood sugar at a single point in time and can reveal patterns that A1c may miss particularly in people with certain hemoglobin variants that affect A1c accuracy
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