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Proc Natl Acad Sci USA., 2021;118:e2022239118
Braun, M
When weight loss occurs gradually, the skin's fibroblasts can continue producing collagen and elastin, allowing it to retract more effectively, but with rapid or significant weight loss, the skin's ability to contract is overwhelmed, leading to lax tissue and an inability to snap back
LR3 adds a 13-residue extension and a position 3 substitution to block binding protein access
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