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The sun protection factor (SPF) of melanin is possibly as high as SPF 4, according to one study 12

Washout periods: for crossover designs, a 7-14 day washout should be adequate given both short serum half-life and the typical decay timeline of tissue-level effects post-dosing

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10.1126/science.aau6499 13 ElsiadE

Brief ROS pulses support normal physiology by tuning cell-fate decisions and adaptive responses, such as aiding sperm capacitation and motility [102], priming lymphocyte activation [103], guiding stem/progenitor differentiation [104], and coordinating wound repair and angiogenesis [105]