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Additionally, "some herbal or 'natural' remedies for constipation, like aloe, cascara, or senna-based products are stimulant-based," says Hamilton, "meaning they work by causing the intestines to contract more forcefully." While these supplements can be effective for short-term relief, Hamilton warns that frequent use can lead to cramping, diarrhea, or dependence

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How GLP-1 Medications Interact With These Pathways Compounded semaglutide and similar GLP-1 receptor agonists address several of these fatigue contributors simultaneously, which is part of why patients often report energy improvements that feel disproportionate to the amount of weight lost