the magnitude of the insulin secretion response to a rise in glucose concentration
Nausea was the most common side effect
When to seek medical advice: Contact your GP for persistent but non-urgent symptoms Use NHS 111 for urgent concerns Attend A&E or call 999 for: Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, dry mouth, decreased urination) Severe abdominal pain, particularly if radiating to the back (possible pancreatitis) Upper right abdominal pain with fever or jaundice (possible gallbladder issues) Severe allergic reaction Inability to tolerate any food or fluids for more than 24 hours Your prescribing clinician may consider delaying dose escalation or temporarily reducing the dose if side effects are particularly troublesome, as outlined in the SmPC
Delayed gastric emptying leaves food and liquid in the stomach longer, increasing stretch and chemical stimulus to visceral afferents that communicate with the brainstem nausea centers
Boneh, A., Beauchamp, M., Humphrey, M., Watkins, J., Peters, H., and Yaplito-Lee, J
