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On April 1, 2026, the FDA approved orforglipron (Foundayo) by Eli Lilly for adults with obesity or overweight who also have weight-related medical problems to reduce excess body weight and maintain weight reduction long term, alongside a reduced-calorie diet and increased physical activity

In FAERS, this GLP-1 RA showed a notable connection with diabetic retinopathy, but its effect was not as prominent in other conditions when compared to other drugs like insulin

The SURMOUNT-1 trial, published in the New England Journal of Medicine, studied tirzepatide - the dual GLP-1 and GIP agonist - in adults with obesity or overweight with at least one weight-related condition over 72 weeks

Slightly uneven texture while the lumps soften

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