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Martchenko et al., 2020)
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Nonetheless, guiding NPs to reach the entire area affected by the pathology without spreading into adjacent healthy tissues is still problematic, often requiring extensive optimization of NPs physiochemical properties (size, charge, stiffness, etc.) (76)
No re-chilling: Generally, if the medication has reached room temperature for an extended period, it is best to use it within that 21-day window rather than putting it back in the fridge and expecting it to last until the original expiration date
Reactive or rosacea-prone skin
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