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Endocrinology 153 , 21982207 (2012)
The target and the pathway in more detail None of the three components has a confirmed cell-surface receptor
This upregulates genes involved in fatty-acid uptake/oxidation, OXPHOS, the TCA cycle, and mitochondrial biogenesis, shifting substrate use toward lipids and increasing energy expenditure
Blocking NNMT raises cellular NAD+, which in research supports fat-cell metabolism and fat loss
Presented for research literature review only Cifuentes ME et al
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