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These works demonstrated that mature macrophages are a cell reservoir in antiretroviral therapy (ART)-suppressed HIV-infected humanized mice [59]
Production rate is directly proportional to cerebral blood flow and plasma osmolality
These oxidative modifications can further activate microglia through DAMP-associated pathways and interestingly, -synuclein misfolding has also been associated with microglia activation (Nagatsu et al., 2000
Neurological: melanocortin receptor activity and central signaling
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