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It is important to note that patients with a history of major depression were actually excluded from the phase 3 randomized controlled trials (RCTs) of these medications 10,11,12,13,14,15,21,22,23
A patented standardized extract of concentrated polyphenols from French maritime pine bark, called Pycnogenol, has been shown to have broad anti-aging effects, and clinical trials indicate it may enhance cognitive function in healthy adults
But the metabolic improvements these compounds produce may be even more significant for long-term health outcomes
H.NoctorG
L.ZhongW.ShuJ.Abu MuchA.LotanD.GrupperA.et al (2021)
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