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Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming

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Total cell surface HA (left), HS (middle), and CS (right) measured in A-498 cells treated or not with hyaluronidase (5 U/mL)

(34) Experimental and clinical studies demonstrate that GLP-1RAs reduce the production of proinflammatory cytokines (e.g., TNF- , IL-6, Interleukin-1 - IL-1) and chemokines (e.g., Monocyte Chemoattractant Protein-1 - MCP-1, CXCL10), while increasing anti-inflammatory cytokines such as Interleukin-10 (IL-10)

The lipid-modifying effects should be considered as part of a broader cardiometabolic benefit profile rather than a primary indication for cholesterol management