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More studies are needed to explore this mechanism further, not least given the advent of medications targeting antioxidant systems which may be an important future therapeutic option in patients with MDD (Simon et al
Peptides 43:4855
Interestingly, GLP-1 RAs work better for weight loss in people without diabetes
Therefore, glutathione appears to mitigate ER stress caused by hypoxia by inhibiting the PERK, IRE1, and ATF6 pathways
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