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A novel triptolide analog downregulates NF-B and induces mitochondrial apoptosis pathways in human pancreatic cancer

Several FDA-approved anti-cancer drugs, including sorafenib, can induce ferroptosis by inhibiting SLC7A11 activity, even though they also elicit apoptosis in preclinical studies [195]

Observations with GLP-1 Agonists: Antibody Reduction: The speaker has witnessed significant reductions in Hashimoto's antibodies among patients using GLP-1agonists, indicating their potential role in managing auto-immune thyroid conditions

Montella R, Malfa P, Giuliano A, Brustia G, Cosson JD, Arlorio M

This is particularly consequential in post-mitotic organs such as the heart and brain, which possess limited regenerative capacity and are exceptionally vulnerable to proteotoxic stress